TMARC Pilot Studies - Completed

Physical Activity & Heart Rate Variability in HIV+/METH+ (Henry)

Agency: TMARC
PI: Henry, Brook, Ph.D.

Abstract

Physical activity (PA) is known to provide significant health benefits, including improving metabolic function, reducing cardiovascular disease, and enhancing neurocognitive ability. PA, defined as any bodily movement involving skeletal muscles that requires energy expenditure, has been proposed as a non-pharmacological intervention to improve health in HIV and prevent drug addiction. Despite potential relevance to neuroAIDS, knowledge about everyday PA in HIV remains limited. While the relationship between exercise and drug use has been characterized in adolescents, remarkably little work has been conducted to assess PA in adults with substance dependence, while comorbid effects of HIV and methamphetamine (METH) dependence on PA have not been investigated. PA is also demonstrated to improve autonomic nervous system (ANS) function, which is impaired in both HIV and METH use, although the combined effect of these factors on ANS activity has not been well characterized. This study will quantify PA in HIV-positive and METH-dependent participants using the International Physical Activity Questionnaire (IPAQ) and assess ANS function by quantifying heart rate variability (HRV). We hypothesize that HIV-infected individuals with comorbid METH dependence will exhibit reduced PA and impaired HRV relative to subjects with either HIV or METH dependence alone. Further, participants with higher PA will exhibit improved HRV compared to more sedentary individuals. We will also explore the potentially predictive relationships among PA, HRV, and cognition. The findings from this project will be used to pursue external funding for studies that assess the efficacy of PA interventions on HIV and METH-induced pathology.

Sponsored by NIH/NIDA P50DA026306

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