TMARC Pilot Studies - Active

Linkage to PrEP Among Men Who Have Sex with Men Using METH (Hoenigl)

Agency: TMARC
PI: Hoenigl, Martin, M.D.

Abstract

We have shown that methamphetamine (METH) use is a likely cause of increased sexual risk behavior in HIV-uninfected men who have sex with men (MSM), and may serve as a major predictor for HIV acquisition in San Diego. Until more effective prevention or treatment interventions are available for METH users, HIV uninfected MSM who use METH may therefore represent ideal candidates for alternative effective prevention interventions, in particular pre-exposure prophylaxis (PrEP). Whether PrEP can sustainably prevent HIV in METH using MSM, however, has to be determined. Our current randomized controlled trial of PrEP adherence in high-risk HIV-uninfected MSM will be completed in March of 2016. This pilot project proposes to leverage the roll off of this clinical trial to determine the effect of METH use on linkage to PrEP during a post-study follow up of 12 months after the end of the trial.  The existing study database will provide the study related risk behavior, drug use and mental health history. We will evaluate METH use and linkage to PrEP based on self-report by using detailed questionnaires during a 12-month post-study follow up in 150 consenting participants of the clinical trial. Focusing on METH users only (n=30), we will further perform frontal system behavior scale (FrSBe) testing, a self-report instrument which is focusing on the domains of executive dysfunction, apathy, and disinhibition, to evaluate patterns that may correlate with reduced linkage and adherence to PrEP and may result ultimately in increased risk of acquiring HIV infection.

Sponsored by NIH/NIDA P50DA026306

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