Dr. Sanjay Mehta presents at 2018 CROI

Dr. Sanjay Mehta presented his TMARC-associated study at the annual Conference on Retroviruses and Opportunistic Infections (CROI) which took place in Boston, Massachusetts, March 4-7th, 2018. CROI is an annual conference that brings together top basic, translational, and clinical researchers from around the world to share the latest studies, important developments, and best research methods in the ongoing battle against HIV/AIDS and related infectious diseases.

Dr. Mehta's project, titled, "Methamphetamine use independently predicts premature aging in HIV+ individuals," aimed to determine the effects of methamphetamine (METH) dependence and HIV on physiologic and functional measures of aging.

The findings from his study suggest that HIV and METH contribute to premature biological aging, with HIV having broader physiologic and epigenetic affects than METH. While consistent with earlier observations, METH was associated with less mtDNA damage, possibly due to induction of autophagy and cell turnover. This may explain the association with improved renal function in METH users, as mitochondrial dysfunction is known to play a significant role in renal disease.

Sponsored by NIH/NIDA P50DA026306

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